Human Genetics, Department of Human Genetics, Genetic Counseling,Gentic Counseling Program, pittsburgh, pgh, pennsylvania, education, university, pitt, graduate school of public health, gsph
Human Genetics, Department of Human Genetics, Genetic Counseling,Gentic Counseling Program, pittsburgh, pgh, pennsylvania, education, university, pitt, graduate school of public health, gsph
Human Genetics, Department of Human Genetics, Genetic Counseling,Gentic Counseling Program, pittsburgh, pgh, pennsylvania, education, university, pitt, graduate school of public health, gsph
Faculty

Human Genetics, Department of Human Genetics, Genetic Counseling,Gentic Counseling Program, pittsburgh, pgh, pennsylvania, education, university, pitt, graduate school of public health, gsph
Zsolt Urban

Position: Associate Professor
Office:A308 Crabtree Hall
130 Desoto St.
Phone:412-648-8269
Email:
CV: View Urban's CV
Education:M.S., Molecular Biology and Biotechology, University of Szeged, 1992
Ph.D., Biology, Robert Wood Johnson Medical School / Semmelweis University of Medicine, 1997
 
Links: Cutis Laxa Research Study


 
About:
Dr. Urban is a molecular geneticist. He received his postdoctoral training at the University of Hawaii and served as an Assistant Professor of Pediatrics at Washington University School of Medicine, St. Louis from 2004 to 2009.

The Urban Lab is focused on inherited diseases of the extracellular matrix, particularly the elastic fiber system. Human genetic diseases under study include supravalvular aortic stenosis, Williams syndrome and cutis laxa. Cellular and zebrafish models are used to identify key molecules and processes of elastic fiber formation and maintenance. The insights from Mendelian diseases and models are applied to understand common, complex diseases such as chronic obstructive pulmonary disease and aneurysms.
 
Research Interests:
Inherited diseases of the extracellular matrix, particularly the elastic fiber, using data on humans and cellular and zebrafish models
 
5 Recent Publications:

GLUT10 Is Required For The Development Of The Cardiovascular System And The Notochord And Connects Mitochondrial Function To TGFβ Signaling
Willaert A, Khatri SM, Callewaert BL, Coucke PJ, Crosby SD, Lee JG, Davis EC, Shiva S, Tsang M, De Paepe A, Urban Z.
Hum Mol Genet 2012 3; 21:1248-1259

Cutis Laxa: A Review
Berk DR, Bentley DD, Lind A, Bayliss SJ, Urban Z
J. Am. Acad. Dermatol. 2012 5; 66:842.e1-842.e17

New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations.
Bert Callewaert, Marjolijn Renard, Vishwanathan Hucthagowder, Beate Albrecht, Ingrid Hausser, Edward Blair, Cristina Dias, Alice Albino, Hiroshi Wachi, Fumiaki Sato, Robert P Mecham, Bart Loeys, Paul J Coucke, Anne De Paepe, Zsolt Urban
Hum. Mutat. 2011 Apr; 32:445-55

Cutis laxa and fatal pulmonary hypertension: a newly recognized syndrome?
Nicola Brunetti-Pierri, Pasquale Piccolo, Eva Morava, Ron A Wevers, Megan McGuirk, Yvette R Johnson, Zsolt Urban, Megan K Dishop, Lorraine Potocki
Clin. Dysmorphol. 2011 Apr; 20:77-81

Mechanisms of emphysema in autosomal dominant cutis laxa.
Qirui Hu, Adrian Shifren, Carla Sens, Jiwon Choi, Zoltan Szabo, Barry C Starcher, Russell H Knutsen, J Michael Shipley, Elaine C Davis, Robert P Mecham, Zsolt Urban
Matrix Biol. 2010 Sep; 29:621-8

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Human Genetics, Department of Human Genetics, Genetic Counseling,Gentic Counseling Program, pittsburgh, pgh, pennsylvania, education, university, pitt, graduate school of public health, gsph