M.D., Medical Degree, McGill University, 1991 Residency, Internal Medicine,, McGill University, 1994 Fellowship, Cardiology, McGill University, 1996 Ph.D., Cardiovascular Sciences, Baylor College of Medicine, 2001 Fellowship, , Genetics, Harvard Medical School and Howard, 2005
Research Interests:
My laboratory uses a wide range of techniques in human and mouse
genetics to elucidate the pathogenesis of hereditary cardiovascular
diseases, such as hypertrophic and dilated cardiomyopathy. Mutations are
mapped and identified in human families and individual patients with
cardiovascular disorders. In addition, we use gene targeting and
transgenic technology to generate novel murine models carrying mutations
previously identified in humans with cardiovascular diseases. These
models are studied to elucidate the pathways linking genotype to
phenotype. Our research is dependent on crosstalk between clinical
studies, human molecular genetic studies, animal modeling, and basic
cellular and molecular studies. We welcome collaborations with other
scientists, clinicians, and patients. Trainees in my laboratory are
exposed to a breadth of techniques in statistical genetics, molecular
genetics, molecular and cell biology, biochemistry, and physiology.
They have the opportunity to pursue projects with clinical or basic
orientations, within a multidisciplinary "bedside to bench to bedside"
environment.
