University of Pittsburgh Department of Human Genetics
Primary Faculty



Secondary Faculty

Naftali Kaminski
Position: Associate Professor
Office:Kauffman 1212
Phone:412-647-3156
Email:
Education:B.A., Medical Degree, Hebrew University-Hadassah, The University of California, San Francisco, 1982
Fellowship, Medicine Functional Genomics, Molecular Biology, 1989
Fellowship, Medicine Functional Genomics, Molecular Biology, 2000
 


Research Interests:
I am interested in understanding the basic mechanisms of pulmonary fibrosis and other advanced lung diseases. My team applies a multihierarchical systems biology approach in which we try to dissect regulatory networks in the lung using expression arrays, high throughput analysis of promoter binding (using Chip on CHIP) of lung disease relevant transcription factors (NFkB, FOXA2, SMAD) and proteomic technologies. On the translational aspect my team focuses on identifying biomarkers for disease presence, progression and response to therapy using expression patterns in peripheral blood mononuclear cells and targeted secreted proteomic of plasma and serum. Computationally we are interested in development of tools and analytical approaches for gene expression analysis and especially in approaches that allow integration of multiple levels of biological and clinical information unto gene expression and gene polymorphism data.
 
Recent Publications:

FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development.
Carsten Stuckenholz, Lili Lu, Prakash Thakur, Naftali Kaminski, Nathan Bahary
Gastroenterology 2009 Oct;137:1321-32

Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.
Chris J Scotton, Malvina A Krupiczojc, Melanie Königshoff, Paul F Mercer, Y C Gary Lee, Naftali Kaminski, John Morser, Joseph M Post, Toby M Maher, Andrew G Nicholson, James D Moffatt, Geoffrey J Laurent, Claudia K Derian, Oliver Eickelberg, Rachel C Chambers
J. Clin. Invest. 2009 Sep;119:2550-63
PMC2735922    

The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease.
Jessica M Bon, Joseph K Leader, Joel L Weissfeld, Harvey O Coxson, Bin Zheng, Robert A Branch, Venkateswarlu Kondragunta, Janet S Lee, Yingze Zhang, Augustine M K Choi, Anna E Lokshin, Naftali Kaminski, David Gur, Frank C Sciurba
PLoS ONE 2009 ;4:e6865
PMC2730536    

Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease.
Thomas J Richards, Aaron Eggebeen, Kevin Gibson, Samuel Yousem, Carl Fuhrman, Bernadette R Gochuico, Noreen Fertig, Chester V Oddis, Naftali Kaminski, Ivan O Rosas, Dana P Ascherman
Arthritis Rheum. 2009 Jul;60:2183-92
PMC2710404    

Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis.
Kazuhisa Konishi, Kevin F Gibson, Kathleen O Lindell, Thomas J Richards, Yingze Zhang, Rajiv Dhir, Michelle Bisceglia, Sebastien Gilbert, Samuel A Yousem, Jin Woo Song, Dong Soon Kim, Naftali Kaminski
Am. J. Respir. Crit. Care Med. 2009 Jul;180:167-75
PMC2714820    

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Kaminski's Links:
Dorothy P. & Richard P. Simmons Center for Interstitial Lung Disease
Detailed research interests and a list of publications
Lung Translational Genomics Center
 
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