Associate Professor of Human Genetics and Biomedical Informatics Associate Director, Center for Simulation and Modeling, University of Pittsburgh Director, Center for Computational Genetics, GSPH Director, Department of Human Genetics Computational Resources Division
My research is primarily concerned with identifying genetic susceptibility loci for common complex disorders. To this end, I apply various methods derived from statistics, genetics, and epidemiology to the analysis of large, typically family-based samples. My current projects include studies of non-insulin dependent diabetes, inflammatory bowel disease, pancreatitis, pancreatic cancer and gastro-esophageal reflux. In addition to studies of diseases, I am also involved in research which describes the quantitative variation associated with non-disease traits, such as thyroid hormone levels. As part of all of these research projects, I am constantly adapting and applying cutting-edge and traditional methods of analysis and also occasionally developing new methods for complex disease analysis. Oh, and I like to ski too...
Genetics of complex diseases; genetics of GI disorders; computational genetics; genetics informatics; genetic epidemiology; bioinformatics
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Adam C Naj, Gyungah Jun, Gary W Beecham, Li-San Wang, Badri Narayan Vardarajan, Jacqueline Buros, Paul J Gallins, Joseph D Buxbaum, Gail P Jarvik, Paul K Crane, Eric B Larson, Thomas D Bird, Bradley F Boeve, Neill R Graff-Radford, Philip L De Jager, Denis Evans, Julie A Schneider, Minerva M Carrasquillo, Nilufer Ertekin-Taner, Steven G Younkin, Carlos Cruchaga, John S K Kauwe, Petra Nowotny, Patricia Kramer, John Hardy, Matthew J Huentelman, Amanda J Myers, Michael M Barmada, F Yesim Demirci, Clinton T Baldwin, Rob Nat. Genet. 2011 May; 43:436-41 PMC3090745