University of Pittsburgh Department of Human Genetics
Primary Faculty



Secondary Faculty

David Clement Whitcomb
Position: Professor
Office:UPMC Presbyterian, Mezzanine level 2, C Wing
Phone:412-648-9604
Email:
Education:M.S., Physiology, The Ohio State University, 1981
Ph.D., Physiology,, The Ohio State University, 1983
M.D., Medical Degree, The Ohio State University,, 1985
Residency, Internal Medicine, Duke University, 1988
Fellowship, Gastroenterology, Duke University, 1991
 


Research Interests:
Dr Whitcomb's interest is in the physiology and pathophysiology of the digestive system, especially the pancreas. He is specifically focusing on complex genetic traits. Dr Whitcomb's laboratory is a world leader in the discovery and understanding of susceptibility genes for acute and chronic pancreatitis. In addition, his laboratory studies genetic factors that modify the response of organs to recurrent injury including fibrosis (e.g. chronic pancreatitis), pain, oncogenesis and functional disorders. Major diseases of interest include hereditary pancreatitis, acute and chronic pancreatitis, an pancreatic cancer. He is using systems biology to integrate the effects of genetic variability, environmental factors and metabolic conditions to model complex human disorders.
 
Recent Publications:

Evaluation and management of autoimmune pancreatitis: experience at a large US center.
Amit Raina, Dhiraj Yadav, Alyssa M Krasinskas, Kevin M McGrath, Asif Khalid, Michael Sanders, David C Whitcomb, Adam Slivka
Am. J. Gastroenterol. 2009 Sep;104:2295-306

Inflammation and pancreatic cancer: an evidence-based review.
Julia B Greer, David C Whitcomb
2009 Aug;9:411-8

Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis.
Arun Sharma, Venkata Muddana, Janette Lamb, Julia Greer, Georgios I Papachristou, David C Whitcomb
Pancreas 2009 Aug

Current management and novel insights in acute pancreatitis.
Venkata Muddana, David C Whitcomb, Georgios I Papachristou
2009 Aug;3:435-44

Angiotensin-converting enzyme gene DD genotype neither increases susceptibility to acute pancreatitis nor influences disease severity.
Nevin Oruc, Georgios I Papachristou, Haritha Avula, Adam Slivka, Janette Lamb, David C Whitcomb
2009 ;11:45-9
PMC2697858    

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Whitcomb's Links:
Pancreas Information resources
Division of Gastroenterology, Hepatology and Nutrition

 
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