University of Pittsburgh Department of Human Genetics
Primary Faculty



Secondary Faculty

Daniel E. Weeks
Position: Professor
of Human Genetics and Biostatistics
Office:A303 Crabtree
Phone:412-624-5388
Email:
CV: View Weeks' CV
Education:B.A., Biology and Mathematics, Colby College, 1983
M.S., Biomathematics, University of California, 1985
Ph.D., Biomathematics (mentored by Kenneth Lange), University of California, 1988
 


About:
Dr. Weeks' research focuses on statistical human genetics in the area of mapping susceptibility loci involved in complex diseases. Dr. Weeks is the Program Director of the International India-US Research Training Program in Genetics. He is also active in external teaching activities, co-leading the annual Wellcome Trust Advanced Course on mapping complex diseases and lecturing in other courses.
 
Research Interests:
Dr. Weeks' research focuses on statistical human genetics in the area of mapping susceptibility loci involved in complex diseases. His primary interest is developing new mapping methods, which involves developing algorithms and statistics, implementing them in computer programs, and testing them on real and simulated data. In addition, he is actively involved in a large number of collaborative disease gene mapping projects, all of which constantly challenge him to develop new and more useful methods for dealing with the complexities of real data. These diseases include age-related macular degeneration, obesity, otitis media, dental caries, pre-term birth, food allergy, autism, and Type II diabetes.
 
Recent Publications:

Otitis media: a genome-wide linkage scan with evidence of susceptibility loci within the 17q12 and 10q22.3 regions.
Margaretha L Casselbrant, Ellen M Mandel, Jeesun Jung, Robert E Ferrell, Kathleen Tekely, Jin P Szatkiewicz, Amrita Ray, Daniel E Weeks
BMC Med. Genet. 2009 ;10:85
PMC2751750    

Association tests using kernel-based measures of multi-locus genotype similarity between individuals.
Indranil Mukhopadhyay, Eleanor Feingold, Daniel E Weeks, Anbupalam Thalamuthu
Genet. Epidemiol. 2009 Aug

Casares' map function: no need for a 'corrected' Haldane's map function.
Daniel E Weeks, Xinyu Tang, Amy M Kwon
Genetica 2009 Apr;135:305-7
PMC2704907    

Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa.
Karolina Aberg, Feng Dai, Guangyun Sun, Ember D Keighley, Subba R Indugula, Sarah T Roberts, Qi Zhang, Diane Smelser, Satupaitea Viali, John Tuitele, Li Jin, Ranjan Deka, Daniel E Weeks, Stephen T McGarvey
Obesity (Silver Spring) 2009 Mar;17:518-24

Interpretation of genetic association studies: markers with replicated highly significant odds ratios may be poor classifiers.
Johanna Jakobsdottir, Michael B Gorin, Yvette P Conley, Robert E Ferrell, Daniel E Weeks
PLoS Genet. 2009 Feb;5:e1000337
PMC2629574    

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Weeks' Links:
Dr. Weeks' Website


 
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