Candace M. Kammerer, Ph.D.

Email: candace.kammerer@mail.hgen.pitt.edu
Phone: (412) 624-7235
Room: A310A Crabtree
Position: Associate Professor, HumanGenetics
Education: B.S., Colorado State University, 1975
Ph.D., Ohio State University, 1979
Research Summary: The major focus of my research is to use statistical genetic methods todetect, characterize, and locate genes that affect quantitative risk factorsof common human diseases. Using data on our large pedigreed baboon population,we are analyzing quantitative risk factors for atherosclerosis andhypertension (with Drs. David Rainwater and Laura Cox). We also are involvedin studies of the genetics of hypertension (with Dr. Larry Atwood) andosteoporosis (with Dr. Braxton Mitchell) using data on large Mexican Americanfamilies. With Dr. Paul Samollow, we are continuing development of geneticlinkage maps for Monodelphis domestica, a South American marsupial used instudies of atherosclerosis and skin cancer. In collaboration with Dr.Rainwater, we recently detected a gene in baboons that affects serumcholesterol levels of low density lipoprotein in response to increased dietarycholesterol.

Representative Publications:

"A DNA polymorphism for lecithin:cholesterol acyltransferase (LCAT) isassociated with high density lipoprotein cholesterol concentrations in baboons."by Kammerer CM, Hixson JE, Mott GE, Atherosclerosis. 98:153-63, 1993.

"NIDDM in Mexican-American families. Heterogeneity by age of onset." byMitchell BD, Kammerer CM, Reinhart LJ, Stern MP, Diab Care 17:567-73, 1994.

"Effects of age, sex, and heredity on measures of bone mass in baboons(Papio hamadryas)" by Kammerer CM, Sparks ML, Rogers J., J MedPrimatol 24:236-42, 1995.

"Genetic and environmental contributions to cardiovascular risk factors inMexican Americans. The San Antonio Family Heart Study." by Mitchell BD,Kammerer CM, Blangero J, Mahaney MC, Rainwater DL, Dyke B, Hixson JE, HenkelRD, Sharp RM, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW,Circulation 94:2159-2170, 1996.

"Two major loci control variation in beta-lipoprotein cholesterol and responseto dietary fat and cholesterol in baboons." by Rainwater DL, Kammerer CM,Hixson JE, Carey KD, Rice KS, Dyke B, VandeBerg JF, Slifer SH, Atwood LD,McGill HC Jr, Vandeberg JL, Arterio Thromb Vasc Biol 18:1061-1068, 1998.

"Sodium lithium countertransport activity is linked to chromosome 5 inbaboons", by Kammerer CM, Cox LA, Mahaney MC, Rogers J, Shade RE,Hypertension, in press.

Other Publications:

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Email:	candace.kammerer@mail.hgen.pitt.edu
Phone:	(412) 624-7235
Room:	A310A Crabtree
Position:	Associate Professor, HumanGenetics
Education:	B.S., Colorado State University, 1975 Ph.D., Ohio State University, 1979
Research Summary:	The major focus of my research is to use statistical genetic methods todetect, characterize, and locate genes that affect quantitative risk factorsof common human diseases. Using data on our large pedigreed baboon population,we are analyzing quantitative risk factors for atherosclerosis andhypertension (with Drs. David Rainwater and Laura Cox). We also are involvedin studies of the genetics of hypertension (with Dr. Larry Atwood) andosteoporosis (with Dr. Braxton Mitchell) using data on large Mexican Americanfamilies. With Dr. Paul Samollow, we are continuing development of geneticlinkage maps for Monodelphis domestica, a South American marsupial used instudies of atherosclerosis and skin cancer. In collaboration with Dr.Rainwater, we recently detected a gene in baboons that affects serumcholesterol levels of low density lipoprotein in response to increased dietarycholesterol.